Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats.

Zheng, Pingping; Lu, Yating; Tang, You; Xu, Fudong; Wang, Lin; Qian, Rui; Hui, Cancan; Xu, Qian; He, Jianle; Deng, Datong

Zheng, Pingping; Lu, Yating; Tang, You; Xu, Fudong; Wang, Lin; Qian, Rui; Hui, Cancan; Xu, Qian; He, Jianle; Deng, Datong.

Afiliación

Zheng P; The General Practice Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Lu Y; The Endocrinology Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Tang Y; The General Practice Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Xu F; The Pathology Department, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, Shoudu Medical University, Beijing, People's Republic of China.
Wang L; The Endocrinology Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Qian R; The Neurology Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Hui C; The Geriatric endocrinology Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Xu Q; The Endocrinology Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
He J; The General Practice Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.
Deng D; The Endocrinology Department, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, People's Republic of China.

Diabetes Metab Syndr Obes ; 16: 2717-2732, 2023.

Article en En | MEDLINE | ID: mdl-37701721

ABSTRACT

ABSTRACT

Background:

To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention.

Methods:

Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCOS rats with metformin, pioglitazone, and acarbose, and we then observed changes in weight, estrus, glucose tolerance, insulin resistance, sex hormones, and hypothalamic kiss1 expression.

Results:

PCOS rats exhibited increased body weight, abnormal estrous cycle, impaired glucose tolerance, insulin resistance, increased testosterone level, increased luteinizing hormone level, and increased Kiss1 expression in the hypothalamus. However, intervention with metformin, pioglitazone, and acarbose improved the reproductive and metabolic disorders as well as reduced hypothalamic Kiss1 expression.

Conclusion:

The expression of hypothalamic Kiss1 may play an important role in the pathogenesis of PCOS. Metformin, pioglitazone, and acarbose may reduce the expression of hypothalamic Kiss1 by improving insulin resistance, thereby improving reproductive and metabolic disorders in PCOS rats.

Palabras clave

PCOS; acarbose; kisspeptin; metformin; pioglitazone; polycystic ovary syndrome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Metab Syndr Obes Año: 2023 Tipo del documento: Article