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Microvascular dysfunction in women with a history of hypertensive disorders of pregnancy: A population-based retrospective cohort study.
Björkman, Stina; Lilliecreutz, Caroline; Bladh, Marie; Strömberg, Tomas; Östgren, Carl Johan; Mahmoud, Arina; Kafashian, Arian; Bergstrand, Sara; Sederholm Lawesson, Sofia.
Afiliación
  • Björkman S; Department of Obstetrics and Gynaecology in Norrköping, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Lilliecreutz C; Department of Obstetrics and Gynaecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Bladh M; Department of Obstetrics and Gynaecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Strömberg T; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
  • Östgren CJ; Department of Health, Medicine and Caring Sciences, and CMIV Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
  • Mahmoud A; Linköping University, Linköping, Sweden.
  • Kafashian A; Linköping University, Linköping, Sweden.
  • Bergstrand S; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
  • Sederholm Lawesson S; Department of Cardiology, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
BJOG ; 131(4): 433-443, 2024 Mar.
Article en En | MEDLINE | ID: mdl-37732494
OBJECTIVE: To evaluate microvascular function in women with previous hypertensive disorders of pregnancy (HDP). DESIGN: Retrospective population-based cohort study. SETTING: Linköping, Sweden. POPULATION: Women aged 50-65 years, participating in the Swedish CArdioPulmonary bioImage Study (SCAPIS) at one site (Linköping) 2016-18, who underwent microcirculatory assessment (N = 1222). METHODS: Forearm skin comprehensive microcirculatory assessment was performed with a PeriFlux PF6000 EPOS (Enhanced Perfusion and Oxygen Saturation) system measuring oxygen saturation and total speed resolved perfusion. Obstetric records were reviewed to identify women with previous HDP. Data on cardiovascular risk factors, comorbidities, medication, lifestyle, anthropometric data, and biochemical analyses were obtained from SCAPIS. The microcirculatory data were compared between women with and without previous HDP. MAIN OUTCOME MEASURES: Skin microcirculatory oxygen saturation and total speed resolved perfusion at baseline and post-ischaemic peak. RESULTS: Women with previous pre-eclampsia displayed impaired post-ischaemic peak oxygen saturation compared with women with normotensive pregnancies (88%, interquartile range [IQR] 84-89% vs 91%, IQR 87-94%, p = 0.001) 6-30 years after pregnancy. The difference remained after multivariable adjustment (ß -2.69, 95% CI -4.93 to -0.45). CONCLUSIONS: The findings reveal microvascular dysfunction at long-term follow up in women with previous pre-eclampsia and strengthen the possible role of endothelial dysfunction as a link to the increased risk of cardiovascular disease in women with HDP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Hipertensión Inducida en el Embarazo Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: BJOG Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Hipertensión Inducida en el Embarazo Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: BJOG Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido