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Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR.
Ploeg, Emily Maria; Samplonius, Douwe Freerk; Xiong, Xiao; Ke, Xiurong; Hendriks, Mark Alexander Johannes Martinus; Britsch, Isabel; van Wijngaarden, Anne Paulien; Zhang, Hao; Helfrich, Wijnand.
Afiliación
  • Ploeg EM; Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands w.helfrich@umcg.nl e.m.ploeg@umcg.nl.
  • Samplonius DF; Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Xiong X; Department of Urology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.
  • Ke X; Faculty of Medical Science and Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou, Guangdong, China.
  • Hendriks MAJM; Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Britsch I; Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
  • van Wijngaarden AP; Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Zhang H; Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Helfrich W; Department of Surgery, Laboratory for Translational Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J Immunother Cancer ; 11(9)2023 09.
Article en En | MEDLINE | ID: mdl-37734877
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido