Your browser doesn't support javascript.
loading
Transjugular intrahepatic portosystemic shunt in patients with hepatocellular carcinoma: A systematic review.
Norero, Blanca; Bosch, Jaume; Berzigotti, Annalisa; Rodrigues, Susana G.
Afiliación
  • Norero B; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Bosch J; Red de Salud UC Christus; Hospital Dr. Sotero del Rio, Santiago, Chile.
  • Berzigotti A; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Rodrigues SG; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
United European Gastroenterol J ; 11(8): 733-744, 2023 10.
Article en En | MEDLINE | ID: mdl-37736854
BACKGROUND/AIMS: Transjugular intrahepatic portosystemic shunts (TIPS) in patients with hepatocellular carcinoma (HCC) may improve access to curative therapies, treat portal hypertension (PH)-related complications without worsening liver function, and increase overall survival. Data on the efficacy and safety of TIPS to treat PH complications in HCC patients, as well as the HCC treatment response, were evaluated. METHODS: Studies reporting efficacy in controlling bleeding/ascites or response to HCC therapy, safety, and survival in patients with HCC and TIPS were searched systematically on PubMed and Embase. An extraction of articles using predefined data fields and quality indicators was used. RESULTS: We selected 19 studies and found 937 patients treated for ascites/bleeding and 177 evaluating HCC treatment response. Over half were under 5 cm and solitary lesions, and most studies included tumours with portal vein thrombosis. Regarding PH studies, TIPS resolved bleeding/ascites in >60% of patients, more effective for bleeding. There were no lethal complications reported and procedural bleeding occurred in <5%. Hepatic encephalopathy occurred in 15%-30% within three months. In the HCC treatment-response studies, major complication rates were low with no mortality. In the studies that evaluated the response to transarterial chemoembolization, complete response rate of patients with TIPS varied from 16% to 75%. Liver transplantation rate varied from 8% to 80%, with >40% rate in half of the studies. CONCLUSIONS: In the published studies, TIPS is effective in treating PH complications in patients with HCC. Prospective studies on TIPS placement in patients with HCC are urgently needed to evaluate the efficacy and safety of TIPS in this setting.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Várices Esofágicas y Gástricas / Quimioembolización Terapéutica / Carcinoma Hepatocelular / Derivación Portosistémica Intrahepática Transyugular / Hipertensión Portal / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Systematic_reviews Límite: Humans Idioma: En Revista: United European Gastroenterol J Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Várices Esofágicas y Gástricas / Quimioembolización Terapéutica / Carcinoma Hepatocelular / Derivación Portosistémica Intrahepática Transyugular / Hipertensión Portal / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Systematic_reviews Límite: Humans Idioma: En Revista: United European Gastroenterol J Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido