HISTOULTRASTRUCTURAL FEATURES OF THYMOCYTES DUE TO THE IMPACT OF THE EXPERIMENTAL GENERAL DEHYDRATION OF A MILD DEGREE.

ABSTRACT

OBJECTIVE: The aim: The objective of the current study was to reveal ultrastructural changes in rats' thymocytes in experimental data in conditions of mild general dehydration. PATIENTS AND METHODS: Materials and methods: The study was conducted on 20 non-linear adult male laboratory rats weighing 150-170 g. Histological and semi-thin slides of the thymus were prepared according to the required guidelines. RESULTS: Results: On average, in the cortical zone of the thymus, there was decreased cellularity by 13.4% (p<0.001), while in the medulla zone this indicator turned out to be unreliable - 5.5% (р=0.19), compared to the indicators in animals of the control group. The study showed that a slight degree of general dehydration of the body causes ultrastructural changes in the thymus and is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ's microstructure, which corresponds to cellular aging and the associated sign of accelerated involution. CONCLUSION: Conclusions: General dehydration of a mild degree in the experiment is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ's microstructure, which corresponds to cellular aging and the associated sign of accelerated involution.