HISTOULTRASTRUCTURAL FEATURES OF THYMOCYTES DUE TO THE IMPACT OF THE EXPERIMENTAL GENERAL DEHYDRATION OF A MILD DEGREE.
Wiad Lek
; 76(8): 1709-1716, 2023.
Article
en En
| MEDLINE
| ID: mdl-37740960
ABSTRACT
OBJECTIVE:
Theaim:
The objective of the current study was to reveal ultrastructural changes in rats' thymocytes in experimental data in conditions of mild general dehydration. PATIENTS ANDMETHODS:
Materials andmethods:
The study was conducted on 20 non-linear adult male laboratory rats weighing 150-170 g. Histological and semi-thin slides of the thymus were prepared according to the required guidelines.RESULTS:
Results:
On average, in the cortical zone of the thymus, there was decreased cellularity by 13.4% (p<0.001), while in the medulla zone this indicator turned out to be unreliable - 5.5% (Ñ=0.19), compared to the indicators in animals of the control group. The study showed that a slight degree of general dehydration of the body causes ultrastructural changes in the thymus and is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ's microstructure, which corresponds to cellular aging and the associated sign of accelerated involution.CONCLUSION:
Conclusions:
General dehydration of a mild degree in the experiment is accompanied by a cell-mediated response of the central link of immunogenesis and results in morphological changes in the thymus, which are atrophic in nature with a typical pattern of remodeling of the organ's microstructure, which corresponds to cellular aging and the associated sign of accelerated involution.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Deshidratación
/
Timocitos
Límite:
Animals
Idioma:
En
Revista:
Wiad Lek
Asunto de la revista:
MEDICINA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Ucrania