Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy.

Senthilkumar, Mohankumar B; Sarangi, Pratiksha; Amit, Sonal; Senguttuvan, Senthilnathan; Kumar, Narendra; Jayandharan, Giridhara R

Senthilkumar, Mohankumar B; Sarangi, Pratiksha; Amit, Sonal; Senguttuvan, Senthilnathan; Kumar, Narendra; Jayandharan, Giridhara R.

Afiliación

Senthilkumar MB; Laurus Center for Gene Therapy, Department of Biological Sciences and Bioengineering and Mehta Family Centre for Engineering in Medicine and Gangwal School of Medical Sciences and Technology, Indian Institute of Technology Kanpur, UP, India.
Sarangi P; Laurus Center for Gene Therapy, Department of Biological Sciences and Bioengineering and Mehta Family Centre for Engineering in Medicine and Gangwal School of Medical Sciences and Technology, Indian Institute of Technology Kanpur, UP, India.
Amit S; Department of Pathology, Government Medical College, Jalaun (Orai), Uttar Pradesh, India.
Senguttuvan S; Commercial Operations, Qiagen India Pvt Ltd., New Delhi, India.
Kumar N; Laurus Center for Gene Therapy, Department of Biological Sciences and Bioengineering and Mehta Family Centre for Engineering in Medicine and Gangwal School of Medical Sciences and Technology, Indian Institute of Technology Kanpur, UP, India.
Jayandharan GR; Laurus Center for Gene Therapy, Department of Biological Sciences and Bioengineering and Mehta Family Centre for Engineering in Medicine and Gangwal School of Medical Sciences and Technology, Indian Institute of Technology Kanpur, UP, India. Electronic address: jayrao@iitk.ac.in.

Thromb Res ; 231: 8-16, 2023 11.

Article en En | MEDLINE | ID: mdl-37741049

Asunto(s)

Hemofilia A; Artropatías; Humanos; Ratones; Animales; Factor VIII/genética; Factor VIII/uso terapéutico; Factor VIII/metabolismo; Factor 6 Asociado a Receptor de TNF/metabolismo; Modelos Animales de Enfermedad; Artropatías/genética; Hemofilia A/complicaciones; Hemofilia A/genética; Hemofilia A/metabolismo

Palabras clave

Adeno-associated viral vectors; Cartilage deterioration; Gene delivery; Hemophilic arthropathy; Inflammation; MicroRNA

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemofilia A / Artropatías Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Thromb Res Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google