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Metastasis suppressor genes in clinical practice: are they druggable?
Gelman, Irwin H.
Afiliación
  • Gelman IH; Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. Irwin.gelman@roswellpark.org.
Cancer Metastasis Rev ; 42(4): 1169-1188, 2023 12.
Article en En | MEDLINE | ID: mdl-37749308
Since the identification of NM23 (now called NME1) as the first metastasis suppressor gene (MSG), a small number of other gene products and non-coding RNAs have been identified that suppress specific parameters of the metastatic cascade, yet which have little or no ability to regulate primary tumor initiation or maintenance. MSG can regulate various pathways or cell biological functions such as those controlling mitogen-activated protein kinase pathway mediators, cell-cell and cell-extracellular matrix protein adhesion, cytoskeletal architecture, G-protein-coupled receptors, apoptosis, and transcriptional complexes. One defining facet of this gene class is that their expression is typically downregulated, not mutated, in metastasis, such that any effective therapeutic intervention would involve their re-expression. This review will address the therapeutic targeting of MSG, once thought to be a daunting task only facilitated by ectopically re-expressing MSG in metastatic cells in vivo. Examples will be cited of attempts to identify actionable oncogenic pathways that might suppress the formation or progression of metastases through the re-expression of specific metastasis suppressors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genes Supresores de Tumor / Nucleósido Difosfato Quinasas NM23 Límite: Humans Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genes Supresores de Tumor / Nucleósido Difosfato Quinasas NM23 Límite: Humans Idioma: En Revista: Cancer Metastasis Rev Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos