Background free <i>in vivo</i><sup>29</sup>Si MR imaging with hyperpolarized PEGylated silicon nanoparticles.

Yang, Seung-Hyun; Kim, Jiwon; Lee, Tae Geol; Park, Mirae; Son, Hye Young; Joo, Chan Gyu; Shim, Jeong Hyun; Lee, Youngbok; Huh, Yong-Min

Background free in vivo²⁹Si MR imaging with hyperpolarized PEGylated silicon nanoparticles.

Yang, Seung-Hyun; Kim, Jiwon; Lee, Tae Geol; Park, Mirae; Son, Hye Young; Joo, Chan Gyu; Shim, Jeong Hyun; Lee, Youngbok; Huh, Yong-Min.

Afiliación

Yang SH; Department of Radiology, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea. YMHUH@yuhs.ac.
Kim J; YUHS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
Lee TG; Department of Bionano Technology, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Republic of Korea. yblee@hanyang.ac.kr.
Park M; Korea Research Institute of Standards and Science, Daejeon, 34113, Republic of Korea. jhshim@kriss.re.kr.
Son HY; Department of Radiology, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea. YMHUH@yuhs.ac.
Joo CG; Department of Radiology, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea. YMHUH@yuhs.ac.
Shim JH; YUHS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
Lee Y; Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
Huh YM; Korea Research Institute of Standards and Science, Daejeon, 34113, Republic of Korea. jhshim@kriss.re.kr.

Analyst ; 148(21): 5355-5360, 2023 Oct 23.

Article en En | MEDLINE | ID: mdl-37750298

ABSTRACT

ABSTRACT

This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolution in vivo29Si MR imaging, emphasizing their biocompatibility and water dispersibility. The acquisition of in vivo Si MR images using the lowest reported dose after subcutaneous and intraperitoneal administration opens new avenues for future 29Si MR studies.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Analyst Año: 2023 Tipo del documento: Article