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Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease.
Kato, Izumi; Ogawa, Yudai; Yakushiji, Fumika; Ogura, Jiro; Kobayashi, Masaki; Shindo, Naoya; Ichikawa, Satoshi; Maenaka, Katsumi; Sakaitani, Masahiro.
Afiliación
  • Kato I; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. maenaka@pharm.hokudai.ac.jp.
  • Ogawa Y; Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. izumi_k@pharm.hokudai.ac.jp.
  • Yakushiji F; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. maenaka@pharm.hokudai.ac.jp.
  • Ogura J; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. maenaka@pharm.hokudai.ac.jp.
  • Kobayashi M; Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo 060-0812, Japan.
  • Shindo N; Department of Pharmacy, Yamagata University Hospital, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata 990-9585, Japan.
  • Ichikawa S; Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. izumi_k@pharm.hokudai.ac.jp.
  • Maenaka K; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. maenaka@pharm.hokudai.ac.jp.
  • Sakaitani M; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Chem Commun (Camb) ; 59(82): 12306-12309, 2023 Oct 12.
Article en En | MEDLINE | ID: mdl-37753573
ABSTRACT
A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón