Magnesium-Mediated Umpolung Carboxylation of <i>p</i>-Quinone Methides with CO<sub>2</sub>.

Yan, Yunying; Hao, Jianjun; Xie, Fenfen; Han, Fen; Jing, Linhai; Han, Pan

Magnesium-Mediated Umpolung Carboxylation of p-Quinone Methides with CO₂.

Yan, Yunying; Hao, Jianjun; Xie, Fenfen; Han, Fen; Jing, Linhai; Han, Pan.

Afiliación

Yan Y; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Hao J; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Xie F; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Han F; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Jing L; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.
Han P; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China.

J Org Chem ; 88(20): 14640-14648, 2023 Oct 20.

Article en En | MEDLINE | ID: mdl-37773013

ABSTRACT

ABSTRACT

Magnesium-mediated reductive carboxylation of p-QMs with CO2 via an Umpolung strategy has been developed, which can be used for the preparation of various aryl acetic acids. This protocol featured high atom economy, mild conditions, and operational simplicity. The creation of this Umpolung carboxylation of p-QMs will unprecedentedly extend the application of p-QMs to nucleophilic reagents.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2023 Tipo del documento: Article País de afiliación: China