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PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development.
Lau, Hwee Hui; Krentz, Nicole A J; Abaitua, Fernando; Perez-Alcantara, Marta; Chan, Jun-Wei; Ajeian, Jila; Ghosh, Soumita; Lee, Yunkyeong; Yang, Jing; Thaman, Swaraj; Champon, Benoite; Sun, Han; Jha, Alokkumar; Hoon, Shawn; Tan, Nguan Soon; Gardner, Daphne Su-Lyn; Kao, Shih Ling; Tai, E Shyong; Gloyn, Anna L; Teo, Adrian Kee Keong.
Afiliación
  • Lau HH; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
  • Krentz NAJ; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Abaitua F; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Perez-Alcantara M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Chan JW; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Ajeian J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Ghosh S; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lee Y; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
  • Yang J; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Thaman S; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Champon B; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
  • Sun H; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Jha A; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Hoon S; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Tan NS; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Gardner DS; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Kao SL; Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Tai ES; Molecular Engineering Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
  • Gloyn AL; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Teo AKK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Nat Commun ; 14(1): 6119, 2023 09 30.
Article en En | MEDLINE | ID: mdl-37777536
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Células Secretoras de Glucagón / Células Secretoras de Insulina / Células Madre Pluripotentes Inducidas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Células Secretoras de Glucagón / Células Secretoras de Insulina / Células Madre Pluripotentes Inducidas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido