Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone-induced toxicities in rats: comparative study with other mitochondrial uncouplers (2,4-dinitrophenol, OPC-163493 and tolcapone).

Inoue, Yuki; Wada, Yuko; Sato, Makoto; Sato, Seiji; Okamoto, Takashi; Kanemoto, Naohide

Inoue, Yuki; Wada, Yuko; Sato, Makoto; Sato, Seiji; Okamoto, Takashi; Kanemoto, Naohide.

Afiliación

Inoue Y; Department of Drug Safety Research, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192 Japan.
Wada Y; PV Operation, Pharmacovigilance Department, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan.
Sato M; Department of Drug Safety Research, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192 Japan.
Sato S; Medicinal Chemistry Research Laboratories, New Drug Research Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Okamoto T; Department of Lead Discovery Research, New Drug Research Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Kanemoto N; Department of Drug Discovery Strategy, Osaka Research Center for Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan.

Toxicol Res ; 39(4): 611-623, 2023 Oct.

Article en En | MEDLINE | ID: mdl-37779591

Palabras clave

Blood toxicity; FCCP; Liver toxicity; Mitochondrial uncoupler; Pancreas toxicity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Toxicol Res Año: 2023 Tipo del documento: Article Pais de publicación: Singapur

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