The role of budesonide intrapolyp injection in the management of type 2 chronic rhinosinusitis with nasal polyps: a randomised clinical trial.
J Laryngol Otol
; 138(4): 416-424, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-37781760
ABSTRACT
PROBLEM:
To assess the efficacy of budesonide intrapolyp injection in chronic rhinosinusitis with nasal polyps.METHOD:
Ninety patients were divided into three groups; group A was given oral prednisolone, group B was given budesonide intrapolyp injection weekly for five consecutive weeks and group C was given budesonide as nasal irrigation for one month. Patients were assessed using Sino-Nasal Outcome Test 22 score, total nasal polyp score, serum immunoglobulin E, absolute eosinophilic count, and morning cortisol level before treatment, one week and three months after completing their treatment.RESULTS:
Total nasal polyp score decreased significantly in all groups compared to those at baseline. Reduction in the oral and injection groups was greater than the wash group (p2 = 0.004), (p3 < 0.001), and the same trend concerning Sino-Nasal Outcome Test 22 score (p2 < 0.001), (p3 < 0.001).CONCLUSION:
Budesonide is an effective agent used in intrapolyp injection with no documented systemic or visual side effects that has comparable results with oral steroids.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinusitis
/
Rinitis
/
Pólipos Nasales
/
Rinosinusitis
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
J Laryngol Otol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Egipto