Regulatory effects of circular RNA on hypoxia adaptation in chicken embryos.
J Anim Sci
; 1012023 Jan 03.
Article
en En
| MEDLINE
| ID: mdl-37788641
The chorioallantoic membrane (CAM) is a key respiratory organ involved in early chicken embryo development. It is abundant in blood vessels and plays an important role in gas exchange in the chicken embryo. Hypoxia, a state of insufficient oxygen, can lead to abnormal angiogenesis. Tibetan chickens (TC), owing to their unique genetic background, have adapted to a hypoxic environment and are able to maintain the balance of angiogenesis. In this study, we aimed to identify potential circular RNAs (circRNAs) and their key regulatory networks related to angiogenesis by comparing highland and lowland chickens. Using RNA sequencing, we identified 93 circRNAs that were differentially expressed in the CAM between highland and lowland chickens. The key circRNAs and circRNA-miRNA-mRNA regulatory networks that affect angiogenesis were constructed using bioinformatic methods. This work provides a novel analysis of the molecular mechanisms of hypoxia adaptation in TC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pollos
/
MicroARNs
Límite:
Animals
Idioma:
En
Revista:
J Anim Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos