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Naturally derived highly resilient and adhesive hydrogels with application as surgical adhesive.
Guo, Zhongwei; Xiong, Yahui; Zhang, Shiqiang; Yuan, Tianying; Xia, Jingjing; Wei, Ronghan; Chen, Lei; Sun, Wei.
Afiliación
  • Guo Z; School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, China.
  • Xiong Y; Department of Burn, Wound Repair & Reconstruction, Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
  • Zhang S; School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, China.
  • Yuan T; Department of Mechanical Engineering and Mechanics, Tsinghua University, Beijing 100084, China.
  • Xia J; Department of Mechanical Engineering and Mechanics, Tsinghua University, Beijing 100084, China. Electronic address: xiajj19@mails.tsinghua.edu.cn.
  • Wei R; School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address: profwei@zzu.edu.cn.
  • Chen L; Department of Burn, Wound Repair & Reconstruction, Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: c
  • Sun W; Department of Mechanical Engineering and Mechanics, Tsinghua University, Beijing 100084, China; Department of Mechanical Engineering, Drexel University, Philadelphia, PA 19104, United States. Electronic address: weisun@mail.tsinghua.edu.cn.
Int J Biol Macromol ; 253(Pt 5): 127192, 2023 Dec 31.
Article en En | MEDLINE | ID: mdl-37793510
ABSTRACT
The inadequacy of conventional surgical techniques for wound closure and repair in soft and resilient tissues may lead to poor healing outcomes such as local tissue fibrosis and contracture. Therefore, the development of adhesive and resilient hydrogels that can adhere firmly to irregular and dynamic wound interfaces and provide a "tension-free proximity" environment for tissue regeneration has become extremely important. Herein, we describe an integrated modeling-experiment-application strategy for engineering a promising hydrogel-based bioadhesive based on recombinant human collagen (RHC) and catechol-modified hyaluronic acid (HA-Cat). Molecular modeling and simulations were used to verify and explore the hypothesis that RHC and HA-Cat can form an assembly complex through physical interactions. The complex was synergistically crosslinked via a catechol/o-quinone coupling reaction and a carbodiimide coupling reactions, resulting in superior hydrogels with strong adhesion and resilience properties. The application of this bioadhesive to tissue adhesion and wound sealing in vivo was successfully demonstrated, with an optimum collagen index, epidermal thickness, and lowest scar width. Furthermore, subcutaneous implantation demonstrated that the bioadhesive exhibited good biocompatibility and degradability. This newly developed hydrogel may be a highly promising surgical adhesive for medical applications, including wound closure and repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adhesivos / Hidrogeles Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adhesivos / Hidrogeles Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: China