CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study.

Giratallah, Haidy; Chenoweth, Meghan J; Pouget, Jennie G; El-Boraie, Ahmed; Alsaafin, Alaa; Lerman, Caryn; Knight, Jo; Tyndale, Rachel F

Giratallah, Haidy; Chenoweth, Meghan J; Pouget, Jennie G; El-Boraie, Ahmed; Alsaafin, Alaa; Lerman, Caryn; Knight, Jo; Tyndale, Rachel F.

Afiliación

Giratallah H; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Chenoweth MJ; Campbell Family Mental Health Research Institute, CAMH, 250 College St, Toronto, ON M5T 1R8, Canada.
Pouget JG; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
El-Boraie A; Campbell Family Mental Health Research Institute, CAMH, 250 College St, Toronto, ON M5T 1R8, Canada.
Alsaafin A; Department of Psychiatry, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Lerman C; Campbell Family Mental Health Research Institute, CAMH, 250 College St, Toronto, ON M5T 1R8, Canada.
Knight J; Department of Psychiatry, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Tyndale RF; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

Hum Mol Genet ; 33(2): 198-210, 2024 Jan 07.

Article en En | MEDLINE | ID: mdl-37802914

Asunto(s)

Neoplasias Pulmonares; Enfermedades Respiratorias; Humanos; Nicotina/genética; Análisis de la Aleatorización Mendeliana; Fumar/efectos adversos; Fumar/genética; Neoplasias Pulmonares/genética; Enfermedades Respiratorias/complicaciones; Citocromo P-450 CYP2A6/genética; Citocromo P-450 CYP2A6/metabolismo

Palabras clave

CYP2A6 weighted genetic risk score; PheWAS; UK Biobank; lung cancer; nicotine metabolism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Respiratorias / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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