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Risk factors for overweight and obesity after childhood acute lymphoblastic leukemia in North America and Switzerland: A comparison of two cohort studies.
Belle, Fabiën N; Schindera, Christina; Ansari, Marc; Armstrong, Gregory T; Beck-Popovic, Maja; Howell, Rebecca; Leisenring, Wendy M; Meacham, Lillian R; Rössler, Jochen; Spycher, Ben D; Tonorezos, Emily; von der Weid, Nicolas X; Yasui, Yutaka; Oeffinger, Kevin C; Kuehni, Claudia E.
Afiliación
  • Belle FN; Childhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Schindera C; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
  • Ansari M; Childhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Armstrong GT; Division of Pediatric Oncology/Hematology, University Children's Hospital Basel, University of Basel, Basel, Switzerland.
  • Beck-Popovic M; Division of Pediatric Oncology and Hematology, Department of Women, Child and Adolescent, University Geneva Hospitals, Cansearch Research platform for pediatric oncology and hematology, Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerlan
  • Howell R; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Tennessee, Memphis, USA.
  • Leisenring WM; Pediatric Hematology-Oncology Unit, University Hospital (CHUV), Lausanne, Switzerland.
  • Meacham LR; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Rössler J; Fred Hutchinson Cancer Center, Washington, Seattle, USA.
  • Spycher BD; Aflac Cancer Center, Children's Healthcare of Atlanta/Emory University, Atlanta, Georgia, USA.
  • Tonorezos E; Division of Pediatric Hematology and Oncology, University Children's Hospital Bern, University of Bern, Bern, Switzerland.
  • von der Weid NX; Childhood Cancer Research Group, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Yasui Y; Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA.
  • Oeffinger KC; Division of Pediatric Oncology/Hematology, University Children's Hospital Basel, University of Basel, Basel, Switzerland.
  • Kuehni CE; Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Tennessee, Memphis, USA.
Cancer Med ; 12(20): 20423-20436, 2023 10.
Article en En | MEDLINE | ID: mdl-37807946
BACKGROUND: After childhood acute lymphoblastic leukemia (ALL), sequelae include overweight and obesity, yet with conflicting evidence. We compared the prevalence of overweight and obesity between ≥5-year ALL survivors from the North American Childhood Cancer Survivor Study (CCSS) and the Swiss Childhood Cancer Survivor Study (SCCSS) and described risk factors. METHODS: We included adult childhood ALL survivors diagnosed between 1976 and 1999. We matched CCSS participants (3:1) to SCCSS participants by sex and attained age. We calculated body mass index (BMI) from self-reported height and weight for 1287 CCSS and 429 SCCSS participants; we then compared those with siblings (2034) in North America and Switzerland (678) siblings. We assessed risk factors for overweight (BMI 25-29.9 kg/m2 ) and obesity (≥30 kg/m2 ) using multinomial regression. RESULTS: We found overweight and obesity significantly more common among survivors in North America when compared with survivors in Switzerland [overweight: 30%, 95% confidence interval (CI): 27-32 vs. 24%, 21-29; obesity: 29%, 27-32 vs. 7%, 5-10] and siblings (overweight: 30%, 27-32 vs. 25%, 22-29; obesity: 24%, 22-26 vs. 6%, 4-8). Survivors in North America [odds ratio (OR) = 1.24, 1.01-1.53] and Switzerland (1.27, 0.74-2.21) were slightly more often obese than siblings. Among survivors, risk factors for obesity included residency in North America (5.8, 3.7-9.0); male (1.7, 1.3-2.3); attained age (≥45 years: 5.1, 2.4-10.8); Non-Hispanic Black (3.4, 1.6-7.0); low household income (2.3, 1.4-3.5); young age at diagnosis (1.6, 1.1-2.2). Cranial radiotherapy ≥18 Gray was only a risk factor for overweight (1.4, 1.0-1.8); steroids were not associated with overweight or obesity. Interaction tests found no evidence of difference in risk factors between cohorts. CONCLUSIONS: Although treatment-related risk for overweight and obesity were similar between regions, higher prevalence among survivors in North America identifies important sociodemographic drivers for informing health policy and targeted intervention trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrepeso / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Child / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrepeso / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Child / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos