Your browser doesn't support javascript.
loading
Impaired glucocorticoid receptor function attenuates herpes simplex virus 1 production during explant-induced reactivation from latency in female mice.
Harrison, Kelly S; Wijesekera, Nishani; Robinson, Anastasia G J; Santos, Vanessa C; Oakley, Robert H; Cidlowski, John A; Jones, Clinton.
Afiliación
  • Harrison KS; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University , Stillwater, Oklahoma, USA.
  • Wijesekera N; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University , Stillwater, Oklahoma, USA.
  • Robinson AGJ; National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, North Carolina, USA.
  • Santos VC; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University , Stillwater, Oklahoma, USA.
  • Oakley RH; National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, North Carolina, USA.
  • Cidlowski JA; National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, North Carolina, USA.
  • Jones C; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University , Stillwater, Oklahoma, USA.
J Virol ; 97(10): e0130523, 2023 10 31.
Article en En | MEDLINE | ID: mdl-37823644
IMPORTANCE: A correlation exists between stress and increased episodes of human alpha-herpes virus 1 reactivation from latency. Stress increases corticosteroid levels; consequently, the glucocorticoid receptor (GR) is activated. Recent studies concluded that a GR agonist, but not an antagonist, accelerates productive infection and reactivation from latency. Furthermore, GR and certain stress-induced transcription factors cooperatively transactivate promoters that drive the expression of infected cell protein 0 (ICP0), ICP4, and VP16. This study revealed female mice expressing a GR containing a serine to alanine mutation at position 229 (GRS229A) shed significantly lower levels of infectious virus during explant-induced reactivation compared to male GRS229A or wild-type parental C57BL/6 mice. Furthermore, female GRS229A mice contained fewer VP16 + TG neurons compared to male GRS229A mice or wild-type mice during the early stages of explant-induced reactivation from latency. Collectively, these studies revealed that GR transcriptional activity has female-specific effects, whereas male mice can compensate for the loss of GR transcriptional activation.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación Viral / Receptores de Glucocorticoides / Herpesvirus Humano 1 / Herpes Simple Límite: Animals Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación Viral / Receptores de Glucocorticoides / Herpesvirus Humano 1 / Herpes Simple Límite: Animals Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos