Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids.
Cell Death Differ
; 30(11): 2432-2445, 2023 11.
Article
en En
| MEDLINE
| ID: mdl-37828085
ABSTRACT
Ferroptosis is a type of cell death characterized by the accumulation of intracellular iron and an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related. Ionizing radiation is a frequently used cancer therapy to kill malignancies. We found that ionizing radiation induces both ferroptosis and autophagy and that there is a form of mutualism between the two processes. Ionizing radiation also causes lipid droplets to form in proximity to damaged mitochondria, which, through the action of mitophagy, results in the degradation of the peridroplet mitochondria by lysosomes and the consequent release of free fatty acids and a significant increase in lipid peroxidation, thus promoting ferroptosis. Ionizing radiation has a stronger, fatal effect on cells with a high level of mitophagy, and this observation suggests a novel strategy for tumor treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ferroptosis
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Cell Death Differ
Año:
2023
Tipo del documento:
Article
País de afiliación:
China