Your browser doesn't support javascript.
loading
Successful treatment of experimental murine vulvovaginal candidiasis with gentian violet.
Bonfim, Amanda P; Sakita, Karina M; Faria, Daniella R; Arita, Glaucia S; Rodrigues-Vendramini, Franciele Av; Capoci, Isis Rg; Braga, Andressa G; Mosca, Valéria Ab; Junior, Admilton Go; Kioshima, Érika S; Bonfim-Mendonça, Patrícia S; Svidzinski, Terezinha Ie.
Afiliación
  • Bonfim AP; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Sakita KM; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Faria DR; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Arita GS; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Rodrigues-Vendramini FA; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Capoci IR; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Braga AG; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Mosca VA; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Junior AG; Electron Microscopy & Microanalysis Laboratory, State University of Londrina, Londrina, PR, 86057-970, Brazil.
  • Kioshima ÉS; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Bonfim-Mendonça PS; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
  • Svidzinski TI; Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
Future Microbiol ; 18: 1137-1146, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37830930
ABSTRACT

Aim:

This study evaluated the antifungal efficacy of gentian violet (GV) in an experimental vulvovaginal candidiasis (VVC) model. Materials &

methods:

In vitro susceptibility and cytotoxicity assays were performed to validate the antifungal potential and safety of GV. The antifungal efficacy was then evaluated in vivo through comparative analysis of the fungal burden following treatment with GV or nystatin, as well as assessment of the vaginal tissue by histology and electron microscopy.

Results:

GV demonstrated a safe antifungal profile against C. albicans, with a significant decrease in fungal burden and an improvement in the inflammatory process evaluated histologically.

Conclusion:

The results of this study motivate further assessment of GV as a promising alternative for VVC therapy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis Vulvovaginal Límite: Animals / Female / Humans Idioma: En Revista: Future Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis Vulvovaginal Límite: Animals / Female / Humans Idioma: En Revista: Future Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil