Relating quanta conservation and compartmental epidemiological models of airborne disease outbreaks in buildings.
Sci Rep
; 13(1): 17335, 2023 10 13.
Article
en En
| MEDLINE
| ID: mdl-37833394
ABSTRACT
We investigate the underlying assumptions and limits of applicability of several documented models for outbreaks of airborne disease inside buildings by showing how they may each be regarded as special cases of a system of equations which combines quanta conservation and compartmental epidemiological modelling. We investigate the behaviour of this system analytically, gaining insight to its behaviour at large time. We then investigate the characteristic timescales of an indoor outbreak, showing how the dilution rate of the space, and the quanta generation rate, incubation rate and removal rate associated with the illness may be used to predict the evolution of an outbreak over time, and may also be used to predict the relative performances of other indoor airborne outbreak models. The model is compared to a more commonly used model, in which it is assumed the environmental concentration of infectious aerosols adheres to a quasi-steady-state, so that the the dimensionless quanta concentration is equal to the the infectious fraction. The model presented here is shown to approach this limit exponentially to within an interval defined by the incubation and removal rates. This may be used to predict the maximum extent to which a case will deviate from the quasi steady state condition.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Transmisibles
/
Contaminación del Aire Interior
Límite:
Humans
Idioma:
En
Revista:
Sci Rep
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido