Schistosoma mansoni: phospholipid methylation and the escape of schistosomula from in vitro cytotoxic reaction.
Mol Biochem Parasitol
; 21(2): 151-9, 1986 Nov.
Article
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| MEDLINE
| ID: mdl-3785293
ABSTRACT
The ability of Schistosoma mansoni schistosomula to evade in vitro cytotoxic activity of antibodies plus complement is shown to be increased by incubation with Concanavalin A (Con A) or with non-immune inactivated human serum. This effect was not observed if S-adenosyl-homocysteine (SAH) a methyltransferase inhibitor was added to the incubation medium. Methyl group incorporation occurs in schistosomulum phospholipids if parasites are incubated in Earle's balanced salt solution. This incorporation is increased by Con A addition and this increase is inhibited by SAH. Supernatants of schistosomula incubated in culture media containing Con A were able to promote phospholipid methylation, showing that methyltransferases were liberated into the culture media. The possible roles played by these phenomena in host-parasite interactions are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Schistosoma mansoni
/
Citotoxicidad Inmunológica
Límite:
Animals
Idioma:
En
Revista:
Mol Biochem Parasitol
Año:
1986
Tipo del documento:
Article