Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes.
Pediatr Obes
; 18(12): e13081, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-37859518
ABSTRACT
BACKGROUND:
Leptin resistance occurs with obesity, but it is unknown if individuals at risk for obesity develop leptin resistance prior to obesity.OBJECTIVE:
Investigate whether leptin resistance is independent of weight status in children at risk for obesity due to intrauterine exposure to maternal obesity or gestational diabetes mellitus (GDM).METHODS:
Mother-child dyads (N = 179) were grouped by maternal pregnancy weight and GDM status (1) normal weight, no GDM; (2) overweight/obesity, no GDM; (3) overweight/obesity with GDM. Children (4-10 years) were further stratified by current body mass index (BMI) <85th or ≥85th percentile. Leptin resistance of children and mothers was calculated as fasting leptin/fat mass index. Two-way ANOVA was used to assess whether leptin concentrations and leptin resistance differed by current weight status or in utero exposure group, after adjusting for race, sex and Tanner stage.RESULTS:
Children with a BMI ≥85th percentile had more leptin resistance than those with a BMI <85th percentile (p < 0.001), but leptin resistance did not differ by in utero exposure. Similarly, leptin resistance in women was associated with weight status and not prior GDM.CONCLUSIONS:
Results suggest that leptin concentrations are associated with obesity but not risk for obesity based on in utero exposure to maternal obesity or GDM.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diabetes Gestacional
/
Obesidad Materna
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Pediatr Obes
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos