A comprehension of signaling pathways and drug resistance; an insight into the correlation between microRNAs and cancer.
Pathol Res Pract
; 251: 154848, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37862919
ABSTRACT
Despite the development of numerous therapies, cancer remains an incurable disease due to various factors, including drug resistance produced by cancer cells. MicroRNAs (miRNAs) regulate different target genes involved in biological and pathological processes, including cancer, through post-transcriptional mechanisms. The development of drug resistance in cancer treatment is a significant barrier because it decreases drug uptake, cellular transport, and changes in proteins involved in cell proliferation, survival, and apoptotic pathways. Numerous studies have found a connection between miRNAs and the development of drug resistance in cancer cells. This paper provides a broad overview of how miRNAs regulate signaling pathways and influence treatment resistance in different cancers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
MicroARNs
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Pathol Res Pract
Año:
2023
Tipo del documento:
Article