Development of super-specific epigenome editing by targeted allele-specific DNA methylation.

Rajaram, Nivethika; Kouroukli, Alexandra G; Bens, Susanne; Bashtrykov, Pavel; Jeltsch, Albert

Rajaram, Nivethika; Kouroukli, Alexandra G; Bens, Susanne; Bashtrykov, Pavel; Jeltsch, Albert.

Afiliación

Rajaram N; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Kouroukli AG; Institute of Human Genetics, University of Ulm and Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Bens S; Institute of Human Genetics, University of Ulm and Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Bashtrykov P; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Jeltsch A; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. albert.jeltsch@ibtb.uni-stuttgart.de.

Epigenetics Chromatin ; 16(1): 41, 2023 10 21.

Article en En | MEDLINE | ID: mdl-37864244

Asunto(s)

Metilación de ADN; ARN Guía de Sistemas CRISPR-Cas; Humanos; Epigénesis Genética; Alelos; Células HEK293; Epigenoma; Sistemas CRISPR-Cas; Edición Génica

Palabras clave

Allele discrimination; DNMT3A/3L; Epigenome editing; Specificity; Targeted DNA methylation; dCas9

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / ARN Guía de Sistemas CRISPR-Cas Límite: Humans Idioma: En Revista: Epigenetics Chromatin Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

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