Defining trophoblast injury patterns in the transcriptomes of dysfunctional placentas.
Placenta
; 143: 87-90, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37866321
ABSTRACT
Trophoblast injury is central to clinically relevant placenta dysfunction. We hypothesized that the mRNA of primary human trophoblasts, exposed to distinct injuries in vitro, capture transcriptome patterns of placental biopsies obtained from common obstetrical syndromes. We deployed a CIBERSORTx deconvolution method to correlate trophoblastic RNAseq-based expression matrices with the transcriptome of omics-defined placental dysfunction patterns in vivo. We found distinct trophoblast injury patterns in placental biopsies from women with fetal growth restriction and a hypertensive disorder, or in biopsies clustered by their omics analysis. Our RNAseq data are useful for defining the contribution of trophoblast injuries to placental dysfunction syndromes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Enfermedades Placentarias
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Placenta
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos