Tracking the cellular immune response from early premalignancy to active multiple myeloma in a new model.

Jadhav, Suchita Suryakant; Luboshits, Galia; Bogen, Bjarne; Firer, Michael A

Jadhav, Suchita Suryakant; Luboshits, Galia; Bogen, Bjarne; Firer, Michael A.

Afiliación

Jadhav SS; Department Chemical Engineering & Biotechnology, Ariel University, Ariel, Israel.
Luboshits G; Department Chemical Engineering & Biotechnology, Ariel University, Ariel, Israel.
Bogen B; Department of Immunology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Firer MA; Department Chemical Engineering & Biotechnology, Ariel University, Ariel, Israel.

Eur J Immunol ; 54(1): e2350627, 2024 Jan.

Article en En | MEDLINE | ID: mdl-37872778

ABSTRACT

ABSTRACT

To calibrate a murine model to study premalignant to malignant multiple myeloma, mice were inoculated with different amounts of myeloma cells, and changes in the immune profile were tracked for over 200 days. The model highlights the development of T-cell exhaustion and suppressor before the appearance of clinical symptoms.

Asunto(s)

Mieloma Múltiple; Lesiones Precancerosas; Animales; Ratones; Mieloma Múltiple/patología; Inmunidad Celular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Mieloma Múltiple Límite: Animals Idioma: En Revista: Eur J Immunol Año: 2024 Tipo del documento: Article País de afiliación: Israel

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