Causal association of metformin and osteoporosis: A 2-sample Mendelian randomization study.
Medicine (Baltimore)
; 102(43): e35191, 2023 Oct 27.
Article
en En
| MEDLINE
| ID: mdl-37904346
To investigate the causal relationship between metformin use and osteoporosis and different subtypes of osteoporosis using a 2-sample Mendelian randomization method. Data from genome-wide association studies were analyzed, with the exposure factor being metformin and the outcome variables being osteoporosis and different subtypes. Mendelian randomization was performed using Inverse Variance Weighted (IVW), MR-Egger, and weight median (WM) methods, and heterogeneity tests, horizontal multivariate analyses, and sensitivity analyses were performed. The IVW method analysis with metformin and osteoporosis showed Pâ
=â
1.53E-04, OR (95%CI)â
=â
1.81E-02 (2.27E-02-1.44E-01); the IVW method analysis with metformin and postmenopausal osteoporosis with pathologic fracture showed Pâ
=â
2.22E-01, OR (95%CI)â
=â
4.89E-02 (3. 83E-04-6.23Eâ
+â
00); the IVW method using metformin with osteoporosis with pathological fracture showed that Pâ
=â
2.14E-01, OR (95%CI)â
=â
1.64Eâ
+â
00(5.78E-02-6.44E-04); the IVW method using metformin with pharmacological osteoporosis with pathological fracture showed that Pâ
=â
9. 83E- 01, OR (95%CI)â
=â
1.11Eâ
+â
00 (3.99E-05-3.11Eâ
+â
04); IVW method of metformin use and pharmacological osteoporosis showed that Pâ
=â
5.99E-01, OR (95%CI)â
=â
2.27Eâ
+â
01 (2.00E-04-2.57Eâ
+â
06); there is a causal relationship between metformin use and osteoporosis, but there is no causal relationship between metformin use and postmenopausal osteoporosis with pathological fracture, osteoporosis with pathological fracture, pharmacological osteoporosis, and pharmacological osteoporosis with pathological fracture, and metformin use is a protective factor for osteoporosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Osteoporosis Posmenopáusica
/
Fracturas Espontáneas
/
Metformina
Límite:
Female
/
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2023
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos