Effects of amyloid ß (Aß)42 and Gasdermin D on the progression of Alzheimer's disease <i>in vitro</i> and <i>in vivo</i> through the regulation of astrocyte pyroptosis.

Hong, Wenjuan; Hu, Chengping; Wang, Can; Zhu, Binggen; Tian, Ming; Qin, Hongyun

Effects of amyloid ß (Aß)42 and Gasdermin D on the progression of Alzheimer's disease in vitro and in vivo through the regulation of astrocyte pyroptosis.

Hong, Wenjuan; Hu, Chengping; Wang, Can; Zhu, Binggen; Tian, Ming; Qin, Hongyun.

Afiliación

Hong W; Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai 200124, China.
Hu C; Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai 200124, China.
Wang C; Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai 200124, China.
Zhu B; Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai 200124, China.
Tian M; Department of Burn, Wound Healing Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Qin H; Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai 200124, China.

Aging (Albany NY) ; 15(21): 12209-12224, 2023 11 02.

Article en En | MEDLINE | ID: mdl-37921870

Asunto(s)

Enfermedad de Alzheimer; Lesiones del Sistema Vascular; Ratones; Animales; Péptidos beta-Amiloides/metabolismo; Enfermedad de Alzheimer/metabolismo; Piroptosis; Proteínas tau/metabolismo; Interleucina-1beta/metabolismo; Astrocitos/metabolismo; Interleucina-18/metabolismo; Gasderminas; Células Endoteliales/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Anexina A5/metabolismo; Anexina A5/farmacología; Eosina Amarillenta-(YS)/metabolismo; Eosina Amarillenta-(YS)/farmacología; Hematoxilina/metabolismo; Hematoxilina/farmacología; Propidio/metabolismo; Propidio/farmacología; Sincalida/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; Factor de von Willebrand; Caspasa 1/metabolismo; ARN Interferente Pequeño/metabolismo; ARN Mensajero/metabolismo; Vasoconstrictores/farmacología; Vasodilatadores/farmacología

Palabras clave

Alzheimer's disease; GSDMD; amyloid ß; astrocyte pyroptosis; endothelial cell

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones del Sistema Vascular / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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