Your browser doesn't support javascript.
loading
Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity.
Xie, Fengjuan; Lin, Yingying; Andersson, Åsa; Vetter, Irina; Zhao, Liang; Wan, JingJing.
Afiliación
  • Xie F; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.
  • Lin Y; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.
  • Andersson Å; Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
  • Vetter I; Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
  • Zhao L; School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Wan J; School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China. jjwan@chem.ecnu.edu.cn.
Chem Commun (Camb) ; 59(93): 13855-13858, 2023 Nov 21.
Article en En | MEDLINE | ID: mdl-37927091
ABSTRACT
Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dendrímeros / Nanopartículas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dendrímeros / Nanopartículas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article