Psychiatric Comorbidities Associated With Keratoconus.
JAMA Ophthalmol
; 141(12): 1145-1150, 2023 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-37943540
ABSTRACT
Importance Evaluating risk factors for keratoconus, often associated with recurrent eye rubbing, could generate hypotheses to be tested in future interventional trials. Objective:
To assess the risk for keratoconus associated with psychiatric comorbidities in adolescents and adults. Design, Setting, andParticipants:
This population-based cross-sectional study included medical records of Israeli adolescents and adults in military service from January 2011 through December 2021. Main Outcomes andMeasures:
The prevalence of anxiety, obsessive compulsive disorder (OCD), autism, and attention-deficit/hyperactivity disorder (ADHD) was evaluated in individuals with and without keratoconus. The association between keratoconus and psychiatric comorbidities was tested using univariate and multivariant analyses.Results:
Overall, 940â¯763 adolescents and adults were included. Mean (SD) age was 17.56 (1.47) years, and 59.3% were male. Keratoconus was documented in 1533 individuals, with a prevalence of 0.16%. Patients with keratoconus were more likely to be diagnosed with ADHD compared with the general population (odds ratio [OR], 1.58; 95% CI, 1.38-1.81; P < .001). After adjusting for age, sex, intellectual status, height, and weight, the results remained unchanged (hazard ratio, 1.46; 95% CI, 1.27-1.67; P < .001). Stratification according to age showed an association between keratoconus and ADHD for males (OR, 1.62; 95% CI, 1.39-1.90; P < .001) but not for females (OR, 1.29; 95% CI, 0.96-1.74; P = .09). Conclusions and Relevance In a large cohort of adolescents and adults, ADHD was associated with a diagnosis of keratoconus in male patients, even after adjusting for possible confounders. Although a causative effect could not be ascribed, these findings support further investigation into the potential value of education regarding eye rubbing in this population.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno por Déficit de Atención con Hiperactividad
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Lobos
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Queratocono
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Trastorno Obsesivo Compulsivo
Límite:
Adolescent
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Adult
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Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
JAMA Ophthalmol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Israel