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Risk Factors Analysis of Severe Liver Injury Induced by Statins.
Su, Feng-Yun; Li, Wen-Hua; Zhao, Xu-Dong; Han, Qian; Xu, Xin; Geng, Tao.
Afiliación
  • Su FY; Department of Pharmacy, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
  • Li WH; Department of Orthopedics, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
  • Zhao XD; Department of Obstetrics and Gynecology, The Affiliated Tai'an City Central Hospital of Qingdao University, Qingdao, China.
  • Han Q; Department of Respiratory, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
  • Xu X; Department of Oncology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
  • Geng T; Department of Pharmacy, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.
Horm Metab Res ; 2024 Jan 03.
Article en En | MEDLINE | ID: mdl-37956980
ABSTRACT
The aim of this study is to report the risk factors of severe statin induced liver injury (SILI). From the database of Shandong ADR Monitoring Center and Outpatients and inpatients in our hospital, SILI cases reported from 2013 to 2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion and exclusion criteria of severe and general SILI were established separately. After the SILI cases were selected and confirmed, the socio-demographic and clinical characteristics were collected. Single factor chi-square test and multi-factor unconditional logistic regression analysis were used to analyze the influencing factors of severe SILI. From 1391 reported cases, 1211 met SILI diagnostic criteria, of which 157 were severe SILI and 964 were general SILI. Univariate analysis showed that age, drug combination, statin category were the influencing factors of severe SILI (p<0.1). Multivariate logistic analysis showed that drug combination and statin category were the influencing factors of severe SILI (p<0.05). Atorvastatin caused the most serious SILI, and its risk is 1.77 times higher than rosuvastatin. The serious SILI risk of drug combination was 2.08 times higher than statin alone. The patient with these factors should be monitored intensively during clinical treatment, to ensure their medication safety.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Horm Metab Res Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Horm Metab Res Año: 2024 Tipo del documento: Article País de afiliación: China
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