Comparative mortality risks in two independent bipolar cohorts.
Psychiatry Res
; 330: 115601, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-37976662
ABSTRACT
OBJECTIVES:
To compare mortality rates in bipolar disorder with common causes of mortality.METHODS:
Observational data from the Prechter Longitudinal Study of Bipolar Disorder (PLS-BD) of 1128 participants including 281 controls was analyzed using logistical regression to quantify mortality rates in comparison with common comorbidities and causes of death. Outcome and treatment measures, including ASRM, GAD-7, PHQ-9 and medication use were used to stratify those with bipolar disorder (BD) that are alive or deceased. A larger cohort of 10,735 existing BD patients with 7,826 controls (no psychiatric diagnosis) from the University of Michigan Health (U-M Health) clinics was used as replication, observational secondary data analysis.RESULTS:
The mortality rates are significantly different between those with BD and controls in both PLS-BD and U-M Health. Those with BD and are deceased have a higher percentage of elevated depression measures but show no difference in mania or anxiety measures nor medication use patterns. In both cohorts, a diagnosis of BD increases the odds of mortality greater than history of smoking or being older than ≥ 60-years of age.CONCLUSION:
BD was found to increase odds of mortality significantly and beyond that of a history of smoking. This finding was replicated in an independent sample.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
Psychiatry Res
Año:
2023
Tipo del documento:
Article