Insight into the effect of ibuprofen on the permeability of the membrane: a molecular dynamic simulation study.

Ghorbani, Mohammad; Dehghan, Gholamreza; Allahverdi, Abdollah

Ghorbani, Mohammad; Dehghan, Gholamreza; Allahverdi, Abdollah.

Afiliación

Ghorbani M; Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Dehghan G; Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Allahverdi A; Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

J Biomol Struct Dyn ; : 1-11, 2023 Nov 20.

Article en En | MEDLINE | ID: mdl-37982256

Ibuprofen changes the physical properties of the membrane.Ibuprofen decreases the packing and intermolecular interaction at the hydrocarbon chain of lipids.Ibuprofen increases the permeability of water and hydrogen peroxide as reactive oxygen species (ROS).Results may shed light on the local cytotoxic side effects of ibuprofen.

Palabras clave

Ibuprofen; a non-steroidal anti-inflammatory drug; permeability of cell membrane; potential of mean force; side effects; umbrella sampling

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomol Struct Dyn Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google