In vitro optimization of crushed drug-sensitive antituberculosis medication when administered via a nasogastric tube.
Microbiol Spectr
; 12(1): e0287623, 2024 Jan 11.
Article
en En
| MEDLINE
| ID: mdl-37991379
ABSTRACT
IMPORTANCE The incidence of tuberculosis (TB) in intensive care units (ICUs) can be as high as 3% in high-burden settings, translating to more than 7,500 patients admitted to the ICU annually. In resource-limited settings, the lack or absence of intravenous formulations of drug-sensitive antituberculosis medications necessitates healthcare practitioners to crush, dissolve, and administer the drugs to critically ill patients via a nasogastric tube (NGT). This off-label practice has been linked to plasma concentrations below the recommended target concentrations, particularly of rifampicin and isoniazid, leading to clinical failure and the development of drug resistance. Optimizing the delivery of crushed drug-sensitive antituberculosis medication via the NGT to critically ill patients is of utmost importance.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Enfermedad Crítica
Límite:
Humans
Idioma:
En
Revista:
Microbiol Spectr
Año:
2024
Tipo del documento:
Article
País de afiliación:
Sudáfrica