[Free radical scavenging agents in myocardial protection during cardiac surgery]. / Les piégeurs de radicaux libres dans la protection myocardique en chirurgie cardiaque.
Ann Cardiol Angeiol (Paris)
; 35(7 Pt 2): 447-52, 1986 Oct 15.
Article
en Fr
| MEDLINE
| ID: mdl-3800287
ABSTRACT
Oxygen free radicals are very unstable metabolites which are produced in abundant quantity during the reoxygenation of an ischemic organ. Oxidation, by these radicals, of the structural lipids of the membranes, is at the origin of cellular lesions all the more extensive as the ischemia, by itself, decreases the ischemic tissue content in "trapping" molecules which usually inactivate those free radicals. Thus, was introduced the concept of an exogenous supply of trappers intended to bring under control the production of radicals and consequently preserve the membrane integrity in the revascularized tissue. This review summarizes, in light of our experience, the results obtained with free radicals trappers in the scope of myocardial preservation, especially in cardiac surgery, and analyzes some of the problems that remain to be resolved before considering the clinical use of these trappers.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Superóxido Dismutasa
/
Peróxidos Lipídicos
/
Malonatos
/
Malondialdehído
/
Infarto del Miocardio
Límite:
Humans
Idioma:
Fr
Revista:
Ann Cardiol Angeiol (Paris)
Año:
1986
Tipo del documento:
Article