DCLK1 and its oncogenic functions: A promising therapeutic target for cancers.

Ye, Liu; Liu, Beibei; Huang, Jingling; Zhao, Xiaolin; Wang, Yuan; Xu, Yungen; Wang, Shuping

Ye, Liu; Liu, Beibei; Huang, Jingling; Zhao, Xiaolin; Wang, Yuan; Xu, Yungen; Wang, Shuping.

Afiliación

Ye L; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Liu B; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Huang J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Zhao X; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Wang Y; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China.
Xu Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: xyg@cpu.edu.cn.
Wang S; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China. Electronic address: wangsp@lzu.edu.cn.

Life Sci ; 336: 122294, 2024 Jan 01.

Article en En | MEDLINE | ID: mdl-38007147

Asunto(s)

Quinasas Similares a Doblecortina; Neoplasias; Neoplasias/diagnóstico; Neoplasias/tratamiento farmacológico; Neoplasias/enzimología; Neoplasias/genética; Quinasas Similares a Doblecortina/antagonistas & inhibidores; Quinasas Similares a Doblecortina/genética; Quinasas Similares a Doblecortina/inmunología; Transición Epitelial-Mesenquimal/genética; Transición Epitelial-Mesenquimal/inmunología; Células Madre Neoplásicas; Reparación del ADN/genética; Reparación del ADN/inmunología; Microambiente Tumoral/genética; Microambiente Tumoral/inmunología; Escape del Tumor/genética; Inhibidores de Proteínas Quinasas/uso terapéutico; Humanos; Isoformas de Proteínas

Palabras clave

DCLK1; DNA repair; Immunotherapy; Metastasis; Stemness; Targeted therapy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinasas Similares a Doblecortina / Neoplasias Límite: Humans Idioma: En Revista: Life Sci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

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