A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing.
J Bacteriol
; 205(12): e0024923, 2023 12 19.
Article
en En
| MEDLINE
| ID: mdl-38009926
ABSTRACT
IMPORTANCE Quorum sensing (QS) is a widespread form of cell-cell signaling that regulates group behaviors important for competition and cooperation within bacterial communities. The QS systems from different bacterial species have diverse properties, but the functional consequences of this diversity are largely unknown. Taking advantage of hyper- and hypo-sensitive QS receptor variants in the opportunistic pathogen Pseudomonas aeruginosa, we examine the costs and benefits of altered signal sensitivity. We find that the sensitivity of a model QS receptor, LasR, impacts the timing and level of quorum gene expression, and fitness during intra- and interspecies competition. These findings suggest competition with kin and with other bacterial species work together to tune signal sensitivity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Pseudomonas
/
Percepción de Quorum
Límite:
Humans
Idioma:
En
Revista:
J Bacteriol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos