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An emerging clade of Chikungunya West African genotype discovered in real-time during 2023 outbreak in Senegal.
Padane, Abdou; Tegally, Houriiyah; Ramphal, Yajna; Seyni, Ndiaye; Sarr, Mariéma; Diop, Mame Matar; Diedhiou, Cyrille Kouligueul; Mboup, Aminata; Diouf, Ndèye Dieyna; Souaré, Abdoulaye; Diagne, Ndéye Diabou; Aza-Gnandji, Marilyne; Dabo, Ndèye Astou; Dia, Yacine Amet; Diaw, Ndeye Aminata; Leye, Nafissatou; Diaw, Papa Alassane; Ahouidi, Ambroise; Cissé, Badara; Diallo, Abdoulaye Samba; Diop, Ousmane; Diallo, Abdou Aziz; Ndoye, Souadou; Sanko, Tomasz J; Baxter, Cheryl; Wilkinson, Eduan; San, James E; Tshabuila, Derek; Naidoo, Yeshnee; Pillay, Sureshnee; Lessells, Richard; Cissé, Khady; Leye, Abdoulaye; Mbaye, Khalifa Ababacar; Kania, Dramane; Tinto, Bachirou; Traoré, Isidore; Kagone, Sampawendé Thérèse; Ouedraogo, Abdoul Salam; Gifford, Robert J; Lourenço, José; Giovanetti, Marta; Giandhari, Jennifer; de Oliveira, Tulio; Mboup, Souleymane.
Afiliación
  • Padane A; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Tegally H; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Ramphal Y; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Seyni N; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Sarr M; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diop MM; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diedhiou CK; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Mboup A; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diouf ND; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Souaré A; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diagne ND; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Aza-Gnandji M; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Dabo NA; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Dia YA; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diaw NA; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Leye N; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diaw PA; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Ahouidi A; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Cissé B; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diallo AS; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diop O; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Diallo AA; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Ndoye S; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Sanko TJ; Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation (IRESSEF), Dakar, Senegal.
  • Baxter C; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Wilkinson E; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • San JE; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Tshabuila D; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Naidoo Y; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Pillay S; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Lessells R; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.
  • Cissé K; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.
  • Leye A; District of Kédougou, Kédougou, Senegal.
  • Mbaye KA; District of Kédougou, Kédougou, Senegal.
  • Kania D; District of Kédougou, Kédougou, Senegal.
  • Tinto B; Centre MURAZ,Bobo-Dioulasso, Burkina Faso.
  • Traoré I; Centre MURAZ,Bobo-Dioulasso, Burkina Faso.
  • Kagone ST; Centre MURAZ,Bobo-Dioulasso, Burkina Faso.
  • Ouedraogo AS; Centre MURAZ,Bobo-Dioulasso, Burkina Faso.
  • Gifford RJ; Centre MURAZ,Bobo-Dioulasso, Burkina Faso.
  • Lourenço J; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
  • Giovanetti M; Universidade Católica Portuguesa, Faculty of Medicine, Biomedical Research Centre, Lisbon, Portugal.
  • Giandhari J; Instituto Rene Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil.
  • de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban 4001, South Africa.
  • Mboup S; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch 7600, South Africa.
medRxiv ; 2023 Nov 15.
Article en En | MEDLINE | ID: mdl-38014099
ABSTRACT
Chikungunya (CHIKV) is a re-emerging endemic arbovirus in West Africa. Since July 2023, Senegal and Burkina Faso have been experiencing an ongoing outbreak, with over 300 confirmed cases detected so far in the regions of Kédougou and Tambacounda in Senegal, the largest recorded outbreak yet. CHIKV is typically maintained in a sylvatic cycle in Senegal but its evolution and factors contributing to re-emergence are so far unknown in West Africa, leaving a gap in understanding and responding to recurrent epidemics. We produced, in real-time, the first locally-generated and publicly available CHIKV whole genomes in West Africa, to characterize the genetic diversity of circulating strains, along with phylodynamic analysis to estimate time of emergence and population growth dynamics. A novel strain of the West African genotype, phylogenetically distinct from strains circulating in previous outbreaks, was identified. This suggests a likely new spillover from sylvatic cycles in rural Senegal and potential of seeding larger epidemics in urban settings in Senegal and elsewhere.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article País de afiliación: Senegal
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2023 Tipo del documento: Article País de afiliación: Senegal