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The roles of tissue-resident macrophages in sepsis-associated organ dysfunction.
Gao, Yulei; Tian, Xin; Zhang, Xiang; Milebe Nkoua, Grace Divine; Chen, Fang; Liu, Yancun; Chai, Yanfen.
Afiliación
  • Gao Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
  • Tian X; Department of Emergency Medicine, China-Congo Friendship Hospital, Brazzaville, 999059, P. R. Congo.
  • Zhang X; Department of Medical Research, Beijing Qiansong Technology Development Company, Beijing, 100193, P. R. China.
  • Milebe Nkoua GD; Department of Medical Research, Sen Sho Ka Gi Company, Inba-gun, Chiba, 285-0905, Japan.
  • Chen F; Department of Emergency Medicine, Rizhao People's Hospital of Shandong Province, Rizhao, 276825, P. R. China.
  • Liu Y; Department of Emergency Medicine, China-Congo Friendship Hospital, Brazzaville, 999059, P. R. Congo.
  • Chai Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
Heliyon ; 9(11): e21391, 2023 Nov.
Article en En | MEDLINE | ID: mdl-38027963
Sepsis, a syndrome caused by a dysregulated host response to infection and characterized by life-threatening organ dysfunction, particularly septic shock and sepsis-associated organ dysfunction (SAOD), is a medical emergency associated with high morbidity, high mortality, and long-term sequelae. Tissue-resident macrophages (TRMs) are a subpopulation of macrophages derived primarily from yolk sac progenitors and fetal liver during embryogenesis, located primarily in non-lymphoid tissues in adulthood, capable of local self-renewal independent of hematopoiesis, and developmentally and functionally restricted to the non-lymphoid organs in which they reside. TRMs are the first line of defense against life-threatening conditions such as sepsis, tumor growth, traumatic-associated organ injury, and surgical-associated injury. In the context of sepsis, TRMs can be considered as angels or demons involved in organ injury. Our proposal is that sepsis, septic shock, and SAOD can be attenuated by modulating TRMs in different organs. This review summarizes the pathophysiological mechanisms of TRMs in different organs or tissues involved in the development and progression of sepsis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido