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An Overview of Supramolecular Platforms Boosting Drug Delivery.
Bellavita, Rosa; Braccia, Simone; Falanga, Annarita; Galdiero, Stefania.
Afiliación
  • Bellavita R; Department of Pharmacy, University of Naples 'Federico II', Naples 80131, Italy.
  • Braccia S; Department of Pharmacy, University of Naples 'Federico II', Naples 80131, Italy.
  • Falanga A; Department of Agricultural Sciences, University of Naples 'Federico II', Portici 80055, Italy.
  • Galdiero S; Department of Pharmacy, University of Naples 'Federico II', Naples 80131, Italy.
Bioinorg Chem Appl ; 2023: 8608428, 2023.
Article en En | MEDLINE | ID: mdl-38028018
ABSTRACT
Numerous supramolecular platforms inspired by natural self-assembly are exploited as drug delivery systems. The spontaneous arrangement of single building blocks into inorganic and organic structures is determined and controlled by noncovalent forces such as electrostatic interactions, π-π interactions, hydrogen bonds, and van der Waals interactions. This review describes the main structures and characteristics of several building blocks used to obtain stable, self-assembling nanostructures tailored for numerous biological applications. Owing to their versatility, biocompatibility, and controllability, these nanostructures find application in diverse fields ranging from drug/gene delivery, theranostics, tissue engineering, and nanoelectronics. Herein, we described the different approaches used to design and functionalize these nanomaterials to obtain selective drug delivery in a specific disease. In particular, the review highlights the efficiency of these supramolecular structures in applications related to infectious diseases and cancer.

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Bioinorg Chem Appl Año: 2023 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Bioinorg Chem Appl Año: 2023 Tipo del documento: Article País de afiliación: Italia