CFD-based bioreactor model with proportional-integral-derivative controller functionality for dissolved oxygen and pH.

Oliveira, Christopher L; Pace, Zoe; Thomas, John A; DeVincentis, Brian; Sirasitthichoke, Chadakarn; Egan, Susan; Lee, Jongchan

Oliveira, Christopher L; Pace, Zoe; Thomas, John A; DeVincentis, Brian; Sirasitthichoke, Chadakarn; Egan, Susan; Lee, Jongchan.

Afiliación

Oliveira CL; Bristol Myers Squibb Company, Global Product Development and Supply, Devens, Massachusetts, USA.
Pace Z; Bristol Myers Squibb Company, Global Product Development and Supply, Devens, Massachusetts, USA.
Thomas JA; Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
DeVincentis B; M-Star Simulations, Ellicott City, Maryland, USA.
Sirasitthichoke C; M-Star Simulations, Ellicott City, Maryland, USA.
Egan S; Bristol Myers Squibb Company, Global Product Development and Supply, Devens, Massachusetts, USA.
Lee J; Bristol Myers Squibb Company, Global Product Development and Supply, Devens, Massachusetts, USA.

Biotechnol Bioeng ; 121(2): 655-669, 2024 Feb.

Article en En | MEDLINE | ID: mdl-38031493

Asunto(s)

Reactores Biológicos; Oxígeno; Oxígeno/química; Técnicas de Cultivo de Célula; Simulación por Computador; Concentración de Iones de Hidrógeno

Palabras clave

CFD; bioreactors; kinetics; process control; transport phenomena

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Reactores Biológicos Idioma: En Revista: Biotechnol Bioeng Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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