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pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.
Philipp, Julian; Dabkowska, Aleksandra; Reiser, Anita; Frank, Kilian; Krzyszton, Rafal; Brummer, Christiane; Nickel, Bert; Blanchet, Clement E; Sudarsan, Akhil; Ibrahim, Mohd; Johansson, Svante; Skantze, Pia; Skantze, Urban; Östman, Sofia; Johansson, Marie; Henderson, Neil; Elvevold, Kjetil; Smedsrød, Bård; Schwierz, Nadine; Lindfors, Lennart; Rädler, Joachim O.
Afiliación
  • Philipp J; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
  • Dabkowska A; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Reiser A; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
  • Frank K; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
  • Krzyszton R; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
  • Brummer C; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
  • Nickel B; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
  • Blanchet CE; European Molecular Biology Laboratory Hamburg Outstation c/o Deutsches Elektronen-Synchrotron, Hamburg 22607, Germany.
  • Sudarsan A; Institute of Physics, University of Augsburg, Augsburg 86159, Germany.
  • Ibrahim M; Institute of Physics, University of Augsburg, Augsburg 86159, Germany.
  • Johansson S; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Skantze P; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Skantze U; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Östman S; Animal Sciences and Technologies, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Johansson M; Animal Sciences and Technologies, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Henderson N; Integrated Bioanalysis, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Elvevold K; Marine Biotechnology, Nofima AS, Tromsø 9291, Norway.
  • Smedsrød B; Vascular Biology Research Group, Department of Medical Biology, University of Tromsø, Tromsø 9019, Norway.
  • Schwierz N; Institute of Physics, University of Augsburg, Augsburg 86159, Germany.
  • Lindfors L; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Gothenburg, Mölndal 431 83, Sweden.
  • Rädler JO; Faculty of Physics and Center for NanoScience, Ludwig Maximilians-University, Munich 80539, Germany.
Proc Natl Acad Sci U S A ; 120(50): e2310491120, 2023 Dec 12.
Article en En | MEDLINE | ID: mdl-38055742
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Liposomas Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Liposomas Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos