A metabolic perspective on nitric oxide function in melanoma.
Biochim Biophys Acta Rev Cancer
; 1879(1): 189038, 2024 01.
Article
en En
| MEDLINE
| ID: mdl-38061664
ABSTRACT
Nitric oxide (NO) generated from nitric oxide synthase (NOS) exerts a dichotomous effect in melanoma, suppressing or promoting tumor progression. This dichotomy is thought to depend on the intracellular NO concentration and the cell type in which it is generated. Due to its central role in the metabolism of multiple critical constituents involved in signaling and stress, it is crucial to explore NO's contribution to the metabolic dysfunction of melanoma. This review will discuss many known metabolites linked to NO production in melanoma. We discuss the synthesis of these metabolites, their role in biochemical pathways, and how they alter the biological processes observed in the melanoma tumor microenvironment. The metabolic pathways altered by NO and the corresponding metabolites reinforce its dual role in melanoma and support investigating this effect for potential avenues of therapeutic intervention.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Melanoma
/
Óxido Nítrico
Límite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos