The orexin receptor 2 (OX2R)-selective agonist TAK-994 increases wakefulness without affecting cerebrospinal fluid orexin levels in cynomolgus monkeys.

Yamada, Ryuji; Narita, Naohiro; Ishikawa, Takashi; Kakehi, Masaaki; Kimura, Haruhide

Yamada, Ryuji; Narita, Naohiro; Ishikawa, Takashi; Kakehi, Masaaki; Kimura, Haruhide.

Afiliación

Yamada R; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Narita N; Drug Metabolism and Pharmacokinetics Laboratory, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Ishikawa T; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Kakehi M; Drug Metabolism and Pharmacokinetics Laboratory, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Kimura H; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: haruhide.kimura@takeda.com.

Pharmacol Biochem Behav ; 234: 173690, 2024 Jan.

Article en En | MEDLINE | ID: mdl-38061670

Asunto(s)

Receptores Acoplados a Proteínas G; Vigilia; Animales; Receptores de Orexina; Orexinas/farmacología; Macaca fascicularis

Palabras clave

Cerebrospinal fluid; OX2R; Orexin; Orexin receptor 2; TAK-994; Wakefulness

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vigilia / Receptores Acoplados a Proteínas G Límite: Animals Idioma: En Revista: Pharmacol Biochem Behav Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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