A rare case of hepatic sinusoidal occlusive syndrome in a premature neonate with trisomy 21.
J Neonatal Perinatal Med
; 16(4): 735-740, 2023.
Article
en En
| MEDLINE
| ID: mdl-38073401
ABSTRACT
Trisomy 21 (Down Syndrome) may lead to multiple hematological and hepatobiliary manifestations including the development of transient abnormal myelopoiesis. While many cases resolve, transient abnormal myelopoiesis may lead to significant morbidity and mortality in a small percentage of patients. This condition may present a diagnostic challenge for physicians and currently there is only limited data on effective treatments, particularly with low blast percent transient abnormal myelopoiesis. We present a case of a neonate with trisomy 21 and multiple congenital anomalies who consequently developed hepatic failure with evidence of non-cirrhotic portal hypertension likely due to transient abnormal myelopoiesis. This clinical scenario highlights the need for additional evaluation for transient abnormal myelopoiesis associated hepatic disorder and possibly hepatic sinusoidal occlusive syndrome among trisomy 21 neonates particularly with low blast percentage.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Down
/
Enfermedades del Recién Nacido
/
Reacción Leucemoide
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
J Neonatal Perinatal Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos