Syntheses of the &#969;-pyridinium-containing very-long-chain ceramides PyrCer(24:1(15Z)) and PyrCer(24:0) and their anticancer activity.

Ko, Ju Young; Kim, Mi-Yeon; Jeon, Ji-Yoon; Jung, Jin Yi; Han, Yong-Hyun; Kim, Jae Hyun

Syntheses of the ω-pyridinium-containing very-long-chain ceramides PyrCer(24:1(15Z)) and PyrCer(24:0) and their anticancer activity.

Ko, Ju Young; Kim, Mi-Yeon; Jeon, Ji-Yoon; Jung, Jin Yi; Han, Yong-Hyun; Kim, Jae Hyun.

Afiliación

Ko JY; Department of Global Innovative Drugs, Chung-Ang University, Seoul 06974, Republic of Korea.
Kim MY; Laboratory of Pathology and Physiology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.
Jeon JY; College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea.
Jung JY; Department of Global Innovative Drugs, Chung-Ang University, Seoul 06974, Republic of Korea.
Han YH; Laboratory of Pathology and Physiology, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea; Multidimensional Genomics Research Center, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: yhhan1015@kangwon.ac.kr.
Kim JH; Department of Global Innovative Drugs, Chung-Ang University, Seoul 06974, Republic of Korea; College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea. Electronic address: jaehyunkim@cau.ac.kr.

Bioorg Med Chem Lett ; 98: 129585, 2024 Jan 15.

Article en En | MEDLINE | ID: mdl-38086468

Asunto(s)

Antineoplásicos; Ceramidas; Esfingolípidos; Ceramidas/farmacología; Ceramidas/química; Ácidos Grasos/farmacología; Compuestos de Piridinio/farmacología; Antineoplásicos/química; Antineoplásicos/farmacología; Carcinoma Hepatocelular/tratamiento farmacológico

Palabras clave

Anticancer activity; Ceramide; Very-long-chain fatty acid; Wittig reaction; ω-pyridinium salt

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingolípidos / Ceramidas / Antineoplásicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

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