Your browser doesn't support javascript.
loading
Personalized medicine in a community health system: the NorthShore experience.
David, Sean P; Dunnenberger, Henry M; Choi, Sarah; DePersia, Allison; Ilbawi, Nadim; Ward, Christopher; Wake, Dyson T; Khandekar, Janardan D; Shannon, Yvette; Hughes, Kristen; Miller, Nicholas; Mangold, Kathy A; Sabatini, Linda M; Helseth, Donald L; Xu, Jianfeng; Sanders, Alan; Kaul, Karen L; Hulick, Peter J.
Afiliación
  • David SP; Department of Family Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Dunnenberger HM; Department of Family Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, United States.
  • Choi S; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • DePersia A; Outcomes Research Network, NorthShore University HealthSystem, Evanston, IL, United States.
  • Ilbawi N; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Ward C; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Wake DT; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Khandekar JD; Outcomes Research Network, NorthShore University HealthSystem, Evanston, IL, United States.
  • Shannon Y; Department of Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Hughes K; Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, United States.
  • Miller N; Department of Family Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Mangold KA; Department of Family Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL, United States.
  • Sabatini LM; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Helseth DL; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Xu J; Department of Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Sanders A; Kellogg Cancer Center, NorthShore University HealthSystem, Evanston, IL, United States.
  • Kaul KL; Mark R. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
  • Hulick PJ; Department of Medicine, NorthShore University HealthSystem, Evanston, IL, United States.
Front Genet ; 14: 1308738, 2023.
Article en En | MEDLINE | ID: mdl-38090148
Genomic and personalized medicine implementation efforts have largely centered on specialty care in tertiary health systems. There are few examples of fully integrated care systems that span the healthcare continuum. In 2014, NorthShore University HealthSystem launched the Center for Personalized Medicine to catalyze the delivery of personalized medicine. Successful implementation required the development of a scalable family history collection tool, the Genetic and Wellness Assessment (GWA) and Breast Health Assessment (BHA) tools; integrated pharmacogenomics programming; educational programming; electronic medical record integration; and robust clinical decision support tools. To date, more than 225,000 patients have been screened for increased hereditary conditions, such as cancer risk, through these tools in primary care. More than 35,000 patients completed clinical genetic testing following GWA or BHA completion. An innovative program trained more than 100 primary care providers in genomic medicine, activated with clinical decision support and access to patient genetic counseling services and digital healthcare tools. The development of a novel bioinformatics platform (FLYPE) enabled the incorporation of genomics data into electronic medical records. To date, over 4,000 patients have been identified to have a pathogenic or likely pathogenic variant in a gene with medical management implications. Over 33,000 patients have clinical pharmacogenomics data incorporated into the electronic health record supported by clinical decision support tools. This manuscript describes the evolution, strategy, and successful multispecialty partnerships aligned with health system leadership that enabled the implementation of a comprehensive personalized medicine program with measurable patient outcomes through a genomics-enabled learning health system model that utilizes implementation science frameworks.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza