Chlordiazepoxide and tonic immobility: a paradoxical enhancement.
Pharmacol Biochem Behav
; 25(6): 1237-43, 1986 Dec.
Article
en En
| MEDLINE
| ID: mdl-3809226
ABSTRACT
Four experiments were conducted with chickens to examine the effects of chlordiazepoxide on tonic immobility, which has been implicated as an innate fear response. Not only did chlordiazepoxide produce a paradoxical dose-dependent increase in the duration of tonic immobility, but birds treated with chlordiazepoxide showed significantly enhanced shock-termination thresholds. Using two separate tolerance paradigms, the enhancement due to chlordiazepoxide was shown to be independent of the sedative and/or muscle relaxant effects of the drug. These findings have interesting implications for the supposed anxiolytic effects of the benzodiazepines and the relationship between fear and serotonin in avian species.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Clordiazepóxido
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1986
Tipo del documento:
Article