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Effect of acute and long-term exercise on leptin levels in depressed outpatients.
Heinen, Darlene; Heissel, Andreas; Heinzel, Stephan; Fydrich, Thomas; Ströhle, Andreas; Rapp, Michael A; Vogel, Heike.
Afiliación
  • Heinen D; Social- and Preventive Medicine, Department of Exercise and Health Sciences, University of Potsdam, Potsdam, Germany.
  • Heissel A; Research Group Molecular and Clinical Life Science of Metabolic Diseases, Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany.
  • Heinzel S; Social- and Preventive Medicine, Department of Sports and Health Sciences, Intra-Faculty Unit Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and E-Health, University of Potsdam, Potsdam, Germany.
  • Fydrich T; Sport-Gesundheitspark Berlin E.V./Zentrum Für Sportmedizin, Berlin, Germany.
  • Ströhle A; Clinical Psychology and Psychotherapy, Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
  • Rapp MA; Institute of Psychology, Department of Educational Sciences and Psychology, TU Dortmund University, Dortmund, Deutschland.
  • Vogel H; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
BMC Public Health ; 23(1): 2509, 2023 12 14.
Article en En | MEDLINE | ID: mdl-38098007
ABSTRACT

BACKGROUND:

Depression is a leading cause of disability worldwide and a significant contributor to the global burden of disease. Altered leptin levels are known to be associated with depressive symptoms, however discrepancies in the results of increased or decreased levels exist. Due to various limitations associated with commonly used antidepressant drugs, alternatives such as exercise therapy are gaining more importance. Therefore, the current study investigates whether depressed patients have higher leptin levels compared to healthy controls and if exercise is efficient to reduce these levels.

METHODS:

Leptin levels of 105 participants with major depressive disorder (MDD; 45.7% female, age mean ± SEM 39.1 ± 1.0) and 34 healthy controls (HC; 61.8% female, age mean ± SEM 36.0 ± 2.0) were measured before and after a bicycle ergometer test. Additionally, the MDD group was separated into three groups two endurance exercise intervention groups (EX) differing in their intensities, and a waiting list control group (WL). Leptin levels were measured pre and post a 12-week exercise intervention or the waiting period.

RESULTS:

Baseline data showed no significant differences in leptin levels between the MDD and HC groups. As expected, correlation analyses displayed significant relations between leptin levels and body weight (HC r = 0.474, p = 0.005; MDD r = 0.198, p = 0.043) and even more with body fat content (HC r = 0.755, p < 0.001; MDD r = 0.675, p < 0.001). The acute effect of the bicycle ergometer test and the 12-week training intervention showed no significant changes in circulating leptin levels.

CONCLUSION:

Leptin levels were not altered in patients with major depression compared to healthy controls and exercise, both the acute response and after 12 weeks of endurance training, had no effect on the change in leptin levels. TRIAL REGISTRATION The study was registered at the German register for clinical studies (DRKS) and the International Clinical Trials Registry Platform of the World Health Organization https//trialsearch.who.int/Trial2.aspx?TrialID=DRKS00008869 on 28/07/2015.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leptina / Trastorno Depresivo Mayor Límite: Female / Humans / Male Idioma: En Revista: BMC Public Health Asunto de la revista: SAUDE PUBLICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leptina / Trastorno Depresivo Mayor Límite: Female / Humans / Male Idioma: En Revista: BMC Public Health Asunto de la revista: SAUDE PUBLICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido